Simultaneous Flow over and under a Gate

This paper reports the results of an investigation carried out to establish the stage-discharge relationship for a flow simultaneously discharging over and under a sluice or a broad-crested gate. The stage-discharge relationship is deduced by a theoretical analysis, based on the application of the Π-theorem of the dimensional analysis and the incomplete self-similarity theory, coupled with an experimental investigation carried out by using a laboratory flume.     

Coexistence of anti-phospholipid antibodies and endothelial perturbation in systemic lupus erythematosus patients with ongoing prothrombotic state

BACKGROUND: Anti-phospholipid antibodies (aPLs) were associated with an ongoing prothrombotic state in patients with systemic lupus erythematosus (SLE). Because aPLs are able to shift endothelial function toward procoagulant activity in vitro, we investigated the relationship among aPLs, ongoing prothrombotic state, and endothelial perturbation in SLE patients. METHODS AND RESULTS: We measured aPLs, anti-EC antibodies, circulating levels of prothrombin fragment F1 + 2 (F1 + 2), tumor necrosis factor-alpha (TNF-alpha), tissue-type plasminogen activator (TPA), and von Willebrand factor (vWF) in 43 SLE patients and 25 healthy subjects. Patients positive for aPLs (n = 23) had a higher prevalence of anti-EC antibodies (P = .02) and higher levels of F1 + 2 (P = .003) than aPL(-) patients. Endothelial perturbation, defined by elevated plasma levels of both TPA and vWF, was significantly associated with aPL positivity (P = .001). F1 + 2 > 1 nmol/L (mean +/- 2 SD of controls) was detected in all but one patient in whom aPL positivity and endothelial perturbation coexisted and in no aPL(+) patient without endothelial perturbation (P = .0039). F1 + 2 was significantly correlated with vWF (rho = .6, P = .004) and TPA (114 = .70, P = .0006) only in aPL(+) patients. Endothelial perturbation was closely associated with high values of TNF-alpha (P = .0001), anti-phospholipid (P = .001), and anti-EC antibodies (P = .012). In 31 patients without a clinical history of thrombosis followed up for 3 years, aPL(+) patients with endothelial perturbation showed higher F1 + 2 and TNF-alpha values than aPL(+) patients without endothelial dysfunction. CONCLUSIONS: This study shows that in SLE patients, aPL positivity is associated with an ongoing prothrombotic state only in the presence of endothelial perturbation. Our findings also suggest that aPLs and TNF-alpha might cooperate in inducing endothelial perturbation.     

Headache in intracerebral hematomas

OBJECTIVES: We sought to describe the frequency and location of headache in intracerebral hematoma (ICH) and to analyze its clinical and CT predictors by means of multivariate analysis. BACKGROUND: Headache is more common in intracerebral hemorrhage than in ischemic stroke, and its frequency varies with hematoma location, but the pathophysiologic mechanisms of headache associated with ICH are not fully known. METHODS: We examined a cohort of 289 patients with ICH during a 14-month period in a university hospital. Clinical, including the presence and location of headache, and CT features were collected by two neurologists. RESULTS: One hundred and sixty-five (57%) patients with ICH had a headache at the onset of their stroke. Headache was more common in cerebellar and lobar hemorrhages than in deep ones (thalamic, caudate, capsuloputaminal, brainstem). Headache was also more common in women, patients younger than 70 years, those who vomited, and those with meningeal signs, a Glasgow Coma Scale score < 10, a hematoma volume > 10 ml or CT evidence of intraventricular or subarachnoid bleeding, moderate to severe hydrocephalus, or transtentorial herniation or midline shift. In multiple logistic regression analysis, only meningeal signs (odds ratio [OR] = 2.3), cerebellar or lobar location (OR = 2.1), transtentorial herniation (OR = 1.8), and female gender (OR = 1.6) were significant predictors of headache at the onset of ICH. CONCLUSIONS: Hematoma location, meningeal signs, and gender are more predictive of headache than hematoma volume, suggesting that headache is more often related to the activation of an anatomically distributed system in susceptible individuals and to subarachnoid bleeding than to intracranial hypertension.     

A Vapor–Liquid–Solid Mechanism for Growing 3C‐SiC Single‐Domain Layers on 6H‐SiC(0001)

Growing device‐quality 3C‐SiC monocrystalline material is still an issue despite two decades of work dedicated to the subject. Using silicon as the substrate generates too many defects in the layers, owing to lattice mismatch, while it is very difficult to control the initial nucleation on an α‐SiC substrate so that 60° rotated domains are randomly formed. Herein, the elaboration of mono‐orientated 3C‐SiC layers on a 6H‐SiC(0001) on‐axis, Si face substrate using a vapor–liquid–solid mechanism is reported. This non‐conventional approach for growing monocrystalline layers involves feeding a Ge–Si melt by a propane flux at a temperature ranging from 1250 to 1550 °C. We show that, by using this technique, the 3C‐SiC material is almost always obtained on an hexagonal substrate, even if the crystal seed is oriented 8° off‐axis. Using on‐axis 6H‐SiC seeds and optimal growth conditions results in the reproducible deposition of single‐domain 3C‐SiC layers. A mechanism is proposed to clarify some aspects of this process.     

On the thermochemistry of the rare earth compounds with thep-block elements

A summary is given of the experimental work carried out to determine the heats of formation of the rare earth compounds with a number of elements of thep-block of the periodic table (in particular Al, In, Sn, Pb, As, Sb, and Bi). The experimental methods and the devices constructed to this end are briefly described and commented on. Some results recently obtained in the thermochemical investigation of binary (Pr-Al and Gd-Pb) and ternary (Ce-Ni-Al and La-Sb-Bi) alloys are presented.     

A Cross-Layer Multi-Hop Simulator for IEEE 802.11e

In this work we simulate the ad hoc mode of IEEE 802.11e for routing optimisation. We simulate the behaviour of routing algorithms at the network layer by using a custom-made cross-layer network simulator developed by our team, which simultaneously considers the physical and Medium Access Control (MAC) layers. Although the simulator also supports the infrastructure mode, in this paper we focus on the ad hoc feature which was introduced by the authors. We opted for the simulator approach over the theoretical analysis, but we also present a mathematical model for IEEE 802.11 ad hoc networks. Some initial tests were performed by using a simple routing algorithm (to evaluate the behaviour of the system in terms of selection of the path between a source and a destination, and the correctness of the calculated metrics, which include end-to-end delay, packets lost, packets delivered), but more advanced cross-layer design solutions were also tested. When information from the physical and MAC layers is used as an input to the routing algorithm, improvements are achieved in the performance of the network. Several functions were compared and the algorithm that privileges shorter links accounting with the metric “collision rate” achieves the best results. When compared with a standard routing solution, this cross-layer approach allows to increase the number of packets delivered, while not significantly affecting the end-to-end delay of the packets.     

The common nodABC genes of Rhizobium meliloti are host-range determinants

Symbiotic bacteria of the genus Rhizobium synthesize lipo-chitooligosaccharides, called Nod factors (NFs), which act as morphogenic signal molecules on legume hosts. The common nodABC genes, present in all Rhizobium species, are required for the synthesis of the core structure of NFs. NodC is an N-acetylglucosaminyltransferase, and NodB is a chitooligosaccharide deacetylase; NodA is involved in N-acylation of the aminosugar backbone. Specific nod genes are involved in diverse NF substitutions that confer plant specificity. We transferred to R. tropici, a broad host-range tropical symbiont, the ability to nodulate alfalfa, by introducing nod genes of R. meliloti. In addition to the specific nodL and nodFE genes, the common nodABC genes of R. meliloti were required for infection and nodulation of alfalfa. Purified NFs of the R. tropici hybrid strain, which contained chitin tetramers and were partly N-acylated with unsaturated C16 fatty acids, were able to elicit nodule formation on alfalfa. Inactivation of the R. meliloti nodABC genes suppressed the ability of the NFs to nodulate alfalfa. Studies of NFs from nodA, nodB, nodC, and nodI mutants indicate that (i) NodA of R. meliloti, in contrast to NodA of R. tropici, is able to transfer unsaturated C16 fatty acids onto the chitin backbone and (ii) NodC of R. meliloti specifies the synthesis of chitin tetramers. These results show that allelic variation of the common nodABC genes is a genetic mechanism that plays an important role in signaling variation and in the control of host range.